Our Academics’ Drug Project to Reduce Insulin Dependence in Diabetes Treatment was Patented

The studies that have the potential to become a medicine, carried out by the academicians of Afyonkarahisar Health Sciences University in accordance with the vision of our university, bear fruit. TÜBİTAK funded project produced from Şuhut Health Services Vocational School Faculty Member Dr. Merve Sen’s thesis received a scientific discovery patent from Turkey Patent and Trademark Institute. Our Rector Prof. Dr. Nurullah Okumuş gave a certificate of appreciation to the academicians who took part in the team that received a scientific invention patent with the drug project to reduce insulin dependence in the treatment of diabetes.

The master thesis titled “The Effect of Epstein Barr Virus Recombinant Proteins EBNA1 and LMP1 on INS1-E (832/13) Beta Cell Culture on Endoplasmic Reticulum (ER) Stress Markers, Apoptosis and Cell Proliferation” completed by Faculty Member Dr. Şen in the Department of Basic Medical Sciences at AFSÜ Faculty of Medicine was patented. In the project team led by his thesis advisor Professor. Dr. Mustafa Altındiş in Sakarya University Faculty of Medicine, Department of Medical Microbiology, Prof. Dr. Sefa Çelik Professor of AFSÜ Faculty of Medicine, Medical Biochemistry and Atatürk Health Services Vocational School Instructors Lecturer Serkan Şen were also present.

The project team, conducted scientific research on INS1-E pancreatic beta cell culture, which synthesizes clonal insulin supplied from Duke University in the USA by Prof. Dr. Sefa Çelik. It was determined that the viral proteins studied within the scope of the project had positive contributions on clonal insulin secretion in the relevant cell line. The results of the related project were presented as oral presentations at the international congress and were awarded with the best oral presentation award in 2018. It was then published as a full text article in an international journal.

After Lecturer Merve Sen’s thesis supported by TUBITAK project completion was made, it was applied to Turkey Patent and Trademark Agency. Related application was defined as “The invention relates to the ability to develop a virotherapeutic agent to be used in antidiabetic therapies, which has the quality to reduce insulin dependence, which can be used in different ways, that positively contributes to insulin secretion.” and was accepted as a scientific invention patent to be protected for a period of seven years.

Lecturer Şen highlighted the importance of interdisciplinary approaches in scientific studies, emphasizing that the data taken under protection within the scope of the invention patent are only those obtained from cell culture studies and these results need to be supported by animal experiments and phase studies.

Our Rector Prof. Dr. Nurullah Okumuş, congratulated the scientists who contributed to the project, especially Mustafa Altındiş, director of the research, who could not come together due to the Covid-19 outbreak measures and also said that such researches are proud on behalf of our country. Prof. Dr. Okumuş stated that the strong academic staff of AFSU will continue to increase their scientific contributions with effective studies.

Güncelleme Tarihi: 29 March 2021